Santhi K. Ganesh, M.D.
Blood Pressure Genetics
Blood pressure is a heritable and major determinant of cardiovascular disease risk and a leading cause of morbidity and mortality in China. The incidence of hypertension is increasing at an alarming rate. Of the trends known to be relevant to cardiovascular diseases, the blood pressure trend is expected to lead to the highest predicted increase in stroke and combined cardiovascular disease in Chinese individuals. In this study, we are studying the association of common and rare genetic variants with blood pressure and hypertension in a cohort of patients at the Peking University First and Third Hospitals. We are also exploring the relationship of genetic determinants for blood pressure with cardiovascular outcomes and other factors known to predict cardiovascular diseases. We have collaborated in a consortium-based genetic analysis of longitudinal BP measures identifying three novel genes influencing BP in the population.