Microbiome / COPD

Margaret R. Gyetko, MD
Principal Investigator UMHS

Margaret R. Gyetko, M.D.

Professor of Internal Medicine
Associate Dean for Faculty Affairs
University of Michigan Medical School
Bei He, MD
Principal Investigator PUHSC

Bei He, M.D.

Professor and Director, Department of Respiratory
Peking University Third Hospital

Microbiome / COPD

Analysis of the Microbiome in Smokers without COPD and with COPD; Comparisons between US and Chinese Populations

Chronic Obstructive Pulmonary Disease (COPD) is a progressive and potentially fatal lung disease, and is a leading cause of death in both the US and China. COPD is most commonly caused by direct smoke exposure and indoor air pollution caused by combustion of biomass fuels. There is currently no curative treatment for COPD. This research aims at determining the respiratory microbiome in healthy non-smokers, "healthy" smokers, and smokers with COPD at various stages, and to determine if a particular microbiome signature is associated with COPD. Data will be collected at both UMHS and PUHSC to compare populations. Many factors that are thought to affect the pulmonary microbiome, such as smoking history, BMI, diet, antibiotic use, and use of biomass fuels in cooking will be observed. This data will provide knowledge that can be used to diagnose COPD at the earliest stages and in the development of novel treatments for COPD.