Yan Zhang, MD
JI program: Cardiovascular
Status: Active/ Ongoing
Cardiovascular disease (CVD) is the leading cause of death globally. Elevated blood pressure (BP), or hypertension (HTN), is a major and heritable risk factor for CVD. Genetic associations with BP/HTN found to date explain little of the variance of BP in the general population, and the mechanisms are largely unknown. This project will investigate the impact of hematologic traits on BP and HTN. The team hypothesizes that genetic variants underlying the joint associations between hematologic and BP traits can be identified using an unbiased genetic association study, and that these findings extend to CVD outcomes.
- Yuan W, Liu Z, Lei W, Sun L,... Li JZ, Yang K ( June 27, 2017). Mutation landscape and intra-tumor heterogeneity of two MANECs of the esophagus revealed by multi-region sequencing. Oncotarget
- Li J, Yan S, Liu Z, … Ke Y. Multiregional sequencing reveal genomic alterations and clonal dynamics in primary malignant melanoma of the esophagus. Cancer Research. 2018;78(2):338-347